Rejuran Healer PN/PDRN – Everything You Need to Know


Rejuran Dr Siew PDRN 3 smallRejuran Healer is a skin healing treatment that has surged in popularity over the last few months. The world cannot seem get enough of skin rejuvenating injection treatments. Skinboosters was the must-have treatment last year, but today, Rejuran Healer, from South Korea has become the treatment on everyone’s lips and minds. Rejuran is also commonly referred to as Rejuran Healer, PN, PDRN Therapy, Miracle Healer Injection, or 婴儿针 (Baby skin injections).

What is Rejuran Healer Treatment?

Rejuran Healer is a rejuvenating skin treatment made of biological molecules called polynucleotides (PN). A PN molecule is a biopolymer made up of 13 or more nucleotide monomers bonded together. If nucleotides sound familiar, it is because you probably heard about it in biology class – nucleotides are the basic structural units which make up DNA!

The DNA extract in Rejuran Healer is obtained from salmon, then fragmented into PNs.

How Does Rejuran Healer Treatment Work?

The 2 main effects of Rejuran Healer, or PN/PDRN are:

  1. Wound healing – through stimulation of growth factors, increased microcirculation,
  2. Anti-inflammatory effects – through scavenging of free radicals and blockage of inflammatory cytokines in the body.

Rejuran biological effects Dr SiewRejuran does this through several mechanisms:

  1. PN/PDRN work by biologically increasing the metabolic activity of cells in the skin called fibroblasts – the fibroblasts in the skin are stimulated to regenerate key components of the skin which we lose with age, such as collagen, glycosaminoglycans and glycoproteins. In other words, PNs awaken tired aged cells to act younger and get to work again.
  2. PN/PDRN act mechanically as a scaffolding for cells and the extracellular matrix to grow – they have a 3-dimensional structure where fibroblasts can use to produce its regenerative effects.
  3. PN/PDRN provide building blocks for DNA synthesis. Through salvage pathways, the PNs are broken down by the body’s processes into purines and pyrimidines, then recycled into new DNA again.

What is the difference between PDRN vs PN?

Polynucleotides (PNs) refer to a broader group of molecules. Deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) are all PNs. On the other hand, PRDN – Polydeoxyribonucleotides, refer to a subtype of PNs. Rejuran contains PNs – which also includes PDRN.

Mechanism of action PDRN
PN/PDRN works by stimulating the Adenosine A2A receptor, and through salvaging DNA fragments.

Much research is focused on PDRN. Studies shows that PDRN may be helpful in healing wounds associated with diabetes1, including foot ulcers2. In animal and in-vitro studies PDRN also helps wound healing, prevent scars 3, and even revive dying skin tissue4 . They work by stimulating the Adenosine receptor A2A receptor (A2A agonist)5.

In Particular, Why is Salmon DNA Used for Skin Rejuvenation?

A study was published in March 2010 to investigate the effect of rubbing salmon DNA on human skin6. The results were surprising – just by doing that, subjects showed a significant improvement in skin elasticity, texture and hydration.

Salmon DNA is used in Rejuran as it is very similar to human DNA. Researchers also found that salmon DNA is very safe and compatible in the human body without causing any adverse side effects. The salmon DNA used in Rejuran is purified to be free from other components such as proteins which may trigger an immune response.

What Benefits Does Rejuran Healer Have?

Rejuran PN/PDRN’s healing properties have several beneficial effects on the skin, as shown in their funded study7:

  • Improved skin elasticity
  • Improved Hydration
  • Reduced fine lines and wrinkles
  • Skin repair – with improved skin barrier function
  • Skin normalization – thickening of skin, regulation of oil production
  • Improved skin tone
  • Improved skin texture

Rejuran effect on skinThe conditions which Rejuran Healer have been shown to treat include:

  • Dark eye circles
  • Enlarged pores
  • Skin sagging
  • Enlarged pores
  • Dull skin
  • Wrinkles and fine lines
  • Acne scars
  • Stretch Marks

What Is the Treatment Process for Rejuran Healer?

Topical numbing cream is applied on the skin for 20 minutes. Your doctor then uses a fine needle to administer tiny amounts of Rejuran Healer under the skin. The treatment takes about 10 minutes to complete. In my practice, I also administer healing LED Red or Infrared Light to sooth the skin and reduce redness and swelling.

Rejuran treatment process
Rejuran Healer is injected into the skin via a tiny needle

What Can You Expect After the Treatment? How Often Do I Need to do it?

As Rejuran Healer treatment is essentially a skin healing procedure, it takes up to 4 weeks to see any visible improvements in your skin – this is because about 4 weeks for PDRN to take effect and repair the skin from the inside. The treatment is best done 3 to 4 times, 2 to 4 weeks apart. Best results are seen only after the last session. Afer that, treatments can be repeated once every 6 – 9 months for maintenance.

It is also important to understand that this is not a facial augmentation using dermal fillers, therefore you are unlikely to see any visible results.

To yield the full benefits of Rejuran Healer treatment, Dr. Siew advises that one should undergo a skin healing program of 3 sessions about 4 weeks apart. This is to ensure that the results are long-lasting and sustainable.

Are There Any Side Effects?

There will be visible bumps on the skin lasting a few hours to a day. Some temporary swelling, and bruising can also occur.

Rejuran downtime
Redness, swelling and bumpiness on the skin typical of a Rejuran treatment. This lasts a few hours to a day.

Rejuran has been reported to react with cross-linked Hyaluronic Acid (HA) fillers, causing granuloma formation (this shows up as hard nodules). The proposed mechanism is through reaction of the polynucleotides with BDDE – the chemical used for cross linking in most fillers. Hence, you are advised NOT to have Rejuran PN/PDRN if you have had cross-linked HA fillers within a year. Speak to your doctor to find out more about this.

This Looks Very Similar to SkinBoosters. What Is the Difference Between Restylane Skinboosters vs Rejuran Healer?

Rejuran Pn PDRN Dr Siew
Rejuran is often compared to Skinboosters, but there are significant differences.

Although both Skinboosters and Rejuran Healer are administered in a rather similar manner, they have different functions and work quite differently.

Restylane SkinBoosters treatment uses hyaluronic acid dermal fillers to provide deep hydration to the dermis. This treatment gives the skin a smoother appearance by plumping up the skin, which leads to reduced appearance of fine lines.

On the other hand, Rejuran Healer treatment takes a more aggressive approach to anti-aging. It actively repairs and heals damaged skin cells and reverses signs of aging to keep the skin young and healthy.

A comparison study shows that Rejuran causes more fibroblast activity, leading to more collagen production, better skin elasticity and more skin thickening.

The table below details the differences between these 2 treatments:

Features Restylane SkinBoosters Rejuran PDRN Healer
Type of Treatment ·      Filler treatment ·      Skin healing and wound repair treatment
Contents ·      Stabilized Hyaluaronic Acid (HA) ·      Polyneucleotide (PN) derived from salmon DNA
What It Does ·      Addresses signs of aging

·      HA draws water to the skin to keep it hydrated and plump

·      Prevents moisture loss

·      Reverses aging by repairing skin at cellular level

·      PDRN/ PN repairs damaged dermal cells

·      Restore abnormal, aging cells

Benefits ·      Rehydrate severely dry skin

·      Smoother skin texture

·      Firmer, more elastic skin

·      Luminous, translucent skin

·      Repair severely damaged skin

·      Reduce appearance of pigmentation and scars

·      Accelerate wound healing

·      Regulate oily skin

·      Minimize enlarged pores

Best For People with ·      Severely dry skin

·      Superficial wrinkles and fine lines

·      Severely damaged, aging skin

·      Scars especially acne scars

·      Enlarged pores with oily skin

Recommended Treatment Plan ·      First 3 treatments to be done 4 weeks apart

·      Subsequent treatments can be done every 6 months

·      First 4 treatments to be done 2 – 4 weeks apart

·      Subsequent treatments can be done every 6 months

Side Effects ·      Skin may appear mildly red and swollen immediately after treatment

·      Injection sites may appear lumpy temporarily if injection depth is too shallow

·      May develop temporary rash

·      Skin may appear mildly red and swollen immediately after treatment

·      Not suitable for vegetarians

In conclusion, both Restylane SkinBoosters and Rejuran Healer treatments work in very different ways to address aging and promote skin rejuvenation. Combining both treatments can achieve better anti-aging and skin rejuvenation effects.

Can Rejuran Healer PN/PDRN be Combined With Other Treatments?

Yes, it can. Like all medical aesthetic treatments, Rejuran can be combined with other treatments to work in synergy to address other skin issues. For example, Rejuran can be done together with Silhouette Soft thread lift or PDO thread lifts to treat skin sagging.

A combination which has benefited many of my patients is using Rejuran with non cross-linked HA fillers – to reap the benefits of skin hydration, skin repair and skin refinement, all at one go in a single skin-refining treatment.

Sounds Fantastic! Is Rejuran Miracle Treatment it is Made Out to be?

Rejuran model 1It is important to note that while PN/PDRN has been shown to be effective in some medical conditions, its use for cosmetic purposes is a fairly recent phenomenon. Most studies done so far are small scale, and more scientific research definitely needs to be done to assess its efficacy and safety.

Already, more research is coming in, with studies proving PN/PDRN’s effectiveness for the skin, and even on the scalp for treating hair loss8 – PN/PDRN can be combined LASEMD laser treatment with PDRN, to restore thinning hair.

It is indeed a promising new treatment – allowing doctors to have even more options to rejuvenate damaged skin. It will not replace other treatments such as dermal fillers, lasers and Ultherapy, but will instead work synergistically with them to give you even better anti-aging results!

  1. Polydeoxyribonucleotide (PDRN): a safe approach to induce therapeutic angiogenesis in peripheral artery occlusive disease and in diabetic foot ulcers. Altavilla D et al.
  2. The effect of PDRN, an adenosine receptor A2A agonist, on the healing of chronic diabeticfoot ulcers: results of a clinical trial. Squadrito F et al
  3. Scar Prevention and Enhanced Wound Healing Induced by Polydeoxyribonucleotidein a Rat Incisional Wound-Healing Model. Jeong W et al
  4. Polydeoxyribonucleotiderestores blood flow in an experimental model of ischemic skin flaps. Polito F et al
  5. Pharmacological Activity and Clinical Use of PDRN Francesco Squadrito et al
  6. Effect of DNA from salmon milt on human skin conditions T.-F. Hsu et al
  7. A Phase III, Randomized, Double-Blind, Matched-Pairs, Active-Controlled Clinical Trial and Preclinical Animal Study to Compare the Durability, Efficacy and Safety between Polynucleotide Filler and Hyaluronic Acid Filler in the Correction of Crow’s Feet: A New Concept of Regenerative Filler Chang Sik Pak et al
  8. Therapeutic Efficacy of 1,927-nm Fractionated Thulium Laser Energy and Polydeoxyribonucleotide on Pattern Hair Loss Sung Bin Cho et al


  1. Hi Dr Siew
    i have tried rejuran for 1 session recently and experienced great results
    I had tear trough & chin fillers from juverderm done 6 months ago.
    Did not experience any granuloma so far. Any advice if i should continue?

    • Hi Amy – thanks for your reply. It is best to go to a doctor so that he can assess your skin before recommending what is best for you. If you like me to take a look, please contact the clinic for an appointment with me. The number is 6837-0507.

  2. I was researching this product and was impressed with you and your website. There are few grammatical errors. I am bilingual so I understand that some things don’t translate well. Fixing them would simply polish a great website.

  3. Dear Dr. Siew,

    I would like to try the Rejuran injection. May I know per treatment cost and what is the total price for the suggested interval above?


  4. Hi Dr Siew,
    If I have 3 skin boosters before, do I still need 3-4times treatment every 3-4weeks for the first around?

    • If you have completed a program of 3 sessions before, you don’t need to do it every 3-4 weeks. You can do it every 6 months or so. If you are keen to drop by the clinic, let me know and we can talk more.

  5. Dear Dr Siew,

    I was wondering if you would recommend Rejuran for someone in his late 20s.
    If done in the long-term, will starting Rejuran relatively young cause any complications in the later years??

    (example: some people believe creams that speed up cell renewal (SK-II etc) should be used at too early an age).

  6. Hello Dr Siew,

    I had co2 laser damage about 4 yrs ago and I’ve tried everything besides another laser. Will never go near another laser. I was left with an orange peel texture, with very enlarged pores all over, will this help? And why countries can I find this treatment?

    Thank you

    • Hi Kam – Sorry to hear about your bad experience with CO2 laser. I am unable to advise if Rejuran is the most suitable treatment for your current skin condition or whether it will improve your skin texture. May I suggest that you see a doctor to get advice on what you can do to improve your skin.

  7. Hi Dr Siew,

    As I read about the article you written about the Rejuran, so is not advisable to do if I did cross link fillers on January 2018 . Can check for eye dropping (sunken eyes lid ) what treatment do you recommend ?

    • Hi Lily,

      Thanks for your message. You might want to get your eyes checked first to determine the cause of the droopy eyelids. There are non-surgical ways to treat droopy eyelids but I will leave it to your doctor to advise you further. Good luck!

  8. Hello Dr. Siew

    I would like to try the rejuran healing injection. May I know how much it’s cost per treatment.
    Thank you

  9. Hi – I’m interested in knowing the cost to see if it’s even in the range of affordability before i come in for consultation. Please advise. Thanks

  10. WOW! My skin has never felt so good. I’m most impressed with the technology…you barely feel anything from the probe, but boy does it work! I noticed a difference after just a few uses. Very pleased with LYFT.

  11. Hi Dr Siew,
    Please advise package price for Rejuran (3 times?). Can it be combined with Restylane Skin Booster? If yes, do you have package price too?


  12. Hi!
    May I know how much is the cost of rejuran per session and how many session are usually needed for depressed scars? I have read that there is also called rejuran s and rejuran healer. Seems that rejuran s is for scars but can rejuran healer be also used for acne scar treatment?

  13. Hi Dr Siew

    I read from another website that there are different Rejuran types of programs for different needs. Eg Rejuran S (higher viscosity) for acne scars. Do you offer different types as well?

    please let me know as I am keen.

    May I know can I make an appointment straight for the session after 1st consultation? If yes, how long will consultation, treatment plus the after treatment last?


  14. Dear Dr Siew
    I’am very keen in doing the Rejuran but the problem is that I’m not staying in Singapore.Is it true that it’s useless if I’m only doing it twice and once more in about three months time.

  15. “To yield the full benefits of Rejuran Healer treatment, Dr. Siew advises that one should undergo a skin healing program of 3 sessions about 4 weeks apart. This is to ensure that the results are long-lasting and sustainable.”

    May I know how much is the whole course of treatment?

  16. Dr.Siew, from which age it’s better to start or to try the Rejuran? I have a normal type of skin, sometimes feel that it’s dry, especially after make up remover. Don’t have any real problems with my skin, but of course want to keep it look young as long as possible. Does it make sense when people say the sooner you prevent the appearance of first wrinkles the longer you will look younger?

  17. Hi Doctor I heard that rejuran will leave the residue in our face not being able to melt away like botox and filler , as you do more the more residue will be left behind . Is it true

    • Hi Jorceline – Thanks for sharing this information with me. This is indeed unusual. I have personally not experienced any permanent residue in the face when I perform the treatment for my patients. There might be some visible swelling and bumps immediately after the treatment but this should subside in a couple of hours or up to a day.

  18. Hi Dr Siew,
    1) How much is it for the Rejuran healer per time? GST included?
    2) How much is your Rejuran healer package and how many times? GST included?
    3) Does it includes LED light & mask after jab?
    4) Is it done manually or thru an injector gun?
    Thank you.

  19. Hi Dr Siew,
    Thanks for the write up.
    My question will be is there any effect to the Rejuran or any filler for the matter , if its combined with laser treatments?
    Which one should one do first?

    Lets say I do laser tribeam package in 1 clinic in monthly, then rejuran with another doctor .. Hows the effect like? Which one you first.

    Appreciate your advice!

  20. Hi Dr Siew,

    Can you email me the price of rejuran and skinboosters package price pls.

    Also, can you advise if your clinic accepts credit card installment free plans, specifically UOB pls.

  21. Hi Dr Siew,
    Can Rejuran still be administered in areas with no fillers? Would that still be beneficial? What is your 3 X package cost? Thanks

  22. Hi Dr siew, do you offer rejuran s treatment for scars and how much are you charging per session? Any side effect and how effective does it help in elevating pitted scars? Thks.

  23. Hi Dr. Siew,

    If I had done below treatments, can I still do the Rejuran?

    12 jan 2018 juvederm voluma
    16 jan 2018 restylane lyft chin

    How much is the Rejuran sessions?

  24. Hi Dr Siew,

    May I know if this treatment works for mild tear trough? I’m male in my late 20s andis bothered by the visible tear trough but worry abt the puffiness from the filler.

    Does this treatment work synergistically with skin boosters as well?

    Do advise on the estimated treatment cost for full face.

    Thank you.

  25. Hi Dr Siew,

    Can you please let me know how much does 1 session of Rejuran cost and if there is a promo for it. Thanks.

  26. Hi Dr Siew,

    Noting that it is not advised to have Rejuran injections if one has had cross-linked HA fillers done within a year, what about if one has had collagen-stimulating fillers done (Radiesse) in less than a year instead? Would Rejuran be okay in this case for the same treated area?
    I would like like to know the cost for Rejuran treatments. Thank you 🙂

  27. Hi Dr Siew,

    Lately, I noticed my pigment is getting worse, cld be due to my increased diving trips.

    I understand that rejuran helps in pigment control.
    Would like to know how much is your rejuran package? How much do you charge for consult too now?

    Visited you twice when you were still at sloane, not sure if you remember though.

    Hear from you soon. Thank you

  28. Hi Dr Siew,

    Can Rejuran be injected right after subcision? How long will the downtime be and what’s the cost?

    Thank you.

  29. Hi Dr Siew
    How many ampules of rejuvan do you typically use on a patient?
    I am 67YO and my “smile wrinkles” are deep would this help?

  30. hi Dr Siew,

    how are you ?

    i am male and i have acne scars and some depressed acne scars,

    more than 10 years ago i went to government national skin centre to trial performed laser treatment on a tiny area by doctor there and the tiny area is ‘bleached’ forever… so bad government doctor… ( i am chinese but a little little bit tanned) … so my problem remain, …

    so now as i heard of rejuran, is rejuran as effective or more effective on acne scars than laser treatment ?

    how much is rejuran per session ? if i do 1 session can i see results , say, how many % improve ? can i just stop at 3 sessions ? how soon can i expect to see result after each session ? is the result permanent ?

    what diffference between rejuran s and rejuran healer ?

    can rejuran treatment be combined with some laser treatment at same time ? is it safe to do both same time , or which to do first and the other thereafter or both at same time ?

    many thank,

    lim, 14.02.19, thu

  31. Dear. DR. Siew

    I appreciate for your kind explanation.

    I am think to get PDRN and HA filler.

    You mentioned about granuloma formation by combination of PDRN and HA filler.

    Do you have any support reference? or is it generally accepted opinion?

    Thank you very much.


    From Hwan Hee OH

  32. hi Siew, i am very interested in rejuran, could you please tell me how much per once and i can not stay in Singapore a month can i have this one once than i buy some?

  33. Hi Dr Siew,

    I had done 3 sessions of restyling skin boosters about 6-7 months ago, do I still need to do a course of 3 sessions of Rejuran healer 4 weeks apart? Also, can do restyling skin boosters and rejuran healer together on the same day? Please advise the cost too, thank you!

  34. Hi Doctor. I had rejuran healer as well as eye this week. Because of the price, do you think I could wait 6 to 8 weeks between the first few sessions?? or is 4 weeks apart better like they suggested?

    • Hi Colette – If this is your first Rejuran program, it might be best for you to stick closely to the given appointment to achieve a long-lasting result.

  35. May I know it is suitable for kidney transplant patient to do it which taken immune suppression medication

    • Hi Krisdadio – Thanks for your message. It is best for you to bring your medicine along when you consult your doctor so that he can tell you if there is any issue.

  36. Hi, I am interested in rejuran. May I know if one session is sufficient? will the delay in taking second sesssion causing the treatment (1st) Not effective? may i know the costs and any LED lights as supplementary treatment to reduce redness? Have read through some articles pertaining to this PDRN.
    Can this substitute botox?

  37. Hi Dr Siew,
    If I undergo a series of microderma pdrn injection, do I have to do maintenance for the rest of my life?
    what would happen if I do not do maintenance at all?

  38. I’m planning to do fillers for my under eye and cheeks. But i also plan to do Rejuran Healer or a Rejuran Healer+Skinbooster combo. Which should come first? As i’m abit confused about the non-cross-linked HA. I scared i’m not supposed to do together.

    • Hi Nick – There are many types of dermal fillers. Not all fillers are suitable for you. To bring out the best results, sometimes a combination of fillers and/or treatments will be required.

      Unfortunately, I won’t be able to answer you right now what you can or cannot do. But it is not uncommon to combine Rejuran with other dermal filler treatments.

      Consult a doctor to work out a suitable plan that works for you.

  39. Your explanation is just phenomenal. I really appreciate your effort and time. I also enjoy your demonstration. Thanks so much for the information. Do you have instagram?

  40. Hi Dr Siew,

    Ive done 2 sessions of rejuran+ha and also pico laser but have not seen any difference. Is this normal? My skin condition is dry and with freckles.

  41. Hi Dr. Siew,
    I am wondering if i need to space apart my rejuran healer injection with other injectible, for example, sculptra and/or fillmed/ filorga ha 135?
    thank you very much for your reply.

    • Hi Cindy, it depends on what other treatments you might be doing together with Rejuran. There might be some treatments that may interact with it and it may not give you optimal results. Best for you to check with your doctor and find out whether there might be any issue in undergoing these treatments together.